It seemed high to me too, when I asked for beta blockers, my doctor said he'd prescribe 40mg, to which I replied 'that seems a bit high, I read online that 10mg-20mg is effective for public speaking', but he just shook his head and said 'you wouldn't even be able to . Effects of ashwagandha (Withania somnifera) on physical performance: systematic review and Bayesian meta-analysis. For example, kratom is one example that has been involved in many seizures. Given the risk of miscarriage, pregnant women should not useashwagandha. Curr Clin Pharmacol. 2013;45(4):417-8. Signs of a very bad reaction. Follow-up and management of valvular heart disease patients with prosthetic valve: a clinical practice guideline for Indian scenario. Complement Ther Med 2016 Aug;27:25-9.View abstract. Ashwagandha has not been well studied in regard to potential interactions with prescription medication. Comments will be approved before showing up. View abstract. Kaur, K., Rani, G., Widodo, N., Nagpal, A., Taira, K., Kaul, S. C., and Wadhwa, R. Evaluation of the anti-proliferative and anti-oxidative activities of leaf extract from in vivo and in vitro raised Ashwagandha. Clipboard, Search History, and several other advanced features are temporarily unavailable. Like easy bruising, bleeding gums, etc. You can check other yohimbine interactions here. Feel free to send him an email at Hello@HelloPharmacist.com! Garlic has been rarely reported to affect blood clotting and may affect people who take, Patients should be advised to limit their consumption of green tea and green tea extracts during treatment with lisinopril, as these products may lower blood levels of the ACE inhibitor, Dried green tea leaves contain vitamin K, which can increase blood clotting. Biogerontology. 2000 Dec;34(12):1478-82. doi: 10.1345/aph.10031. HHS Vulnerability Disclosure, Help Medicine (Baltimore). View abstract. Staff. View abstract. Accessibility Ahmad MK, Mahdi AA, Shukla KK, et al. 2005;65(9):1239-82. doi: 10.2165/00003495-200565090-00005. Most clinical research supports valerian's use to relieve insomnia and improve sleep quality. Most importantly, what are the side effects of Ashwagandhato be aware of? Effect of Indian Ayurvedic medicine Ashwagandha on measurement of serum digoxin and 11 commonly monitored drugs using immunoassays: study of protein binding and interaction with Digibind. Samuels N. Herbal remedies and anticoagulant therapy. View abstract. As a medication, Lexapro does have a list of other medicines where interaction is possible. Since you don't mention any drugs in your question, we'll list some of the potential interactions below. Ashwagandha is used as a tonic (it is sometimes referred to as the Indian ginseng) to improve physical and mental health and to treat a number of specific conditions. View abstract. Indian J Physiol Pharmacol. WE CANNOT DIAGNOSE YOU OVER THE INTERNET. View abstract. It also comes an herbal supplement in capsules, liquids, and even gummies and chewing gum at retail outlets. This includes people who have had a transplant, are on chemo, or have an autoimmune disease. View abstract. There is some preliminary research that it may help with epilepsy and memory loss, but these results are too early to say for sure if it could benefit humans. Malviya, N., Jain, S., Gupta, V. B., and Vyas, S. Recent studies on aphrodisiac herbs for the management of male sexual dysfunction--a review. 2011;68(1):3-8. Bhattacharya, S. K., Bhattacharya, A., Sairam, K., and Ghosal, S. Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: an experimental study. This is often linked to taking too high of a dose and can be remediated by taking smaller doses. The Gale Encyclopedia of Alternative Medicine, third edition, 2009. We study millions of patients and 5,000 more each day. + FREE GIFT ON ORDERS OF $200! Today, many herbal supplements and nutraceuticals can be purchased over-the-counter (OTC) and may be labeled "all-natural". This is called a medicine interaction. Malhotra, C. L., Mehta, V. L., Das, P. K., and Dhalla, N. S. Studies on Withania-ashwagandha, Kaul. Likewise, the effects of ashwagandha in nursing . An interaction impacts how a drug works and might increase or reduce the effects of the said medicine. Ashwagandha has not been linked to weight gain in any significant capacity. Indian J Exp Biol. 2013;12(4):312-22. Arch Intern Med 1998:158;2200-11. Dongre S, Langade D, Bhattacharyya S. Efficacy and safety of ashwagandha (withania somnifera) root extract in improving sexual function in women: a pilot study. Federal government websites often end in .gov or .mil. For some people, melatonin tablets may be helpful for insomnia, jet lag and shift work sleep disorder. Create an account to follow your favorite communities and start taking part in conversations. In a review article published in March 2014, 38 herbs were reviewed and were found to clinically interact with warfarin. There is no drug interaction reported. The health professionals who are involved in treating the patients are expected to be fully informed about the interactions between warfarin and medicinal herbs in order to minimize the health risks of the patients. Interactions of warfarin with garlic, ginger, ginkgo, or ginseng: nature of the evidence. Do not stop using any medications without first talking to your doctor. There are over 180 drug interactions with garlic, but most are reported as minor. 1 min read; Jun 05, 2022; Bagikan : parade of homes matterport . Bonilla DA, Moreno Y, Gho C, Petro JL, Odriozola-Martnez A, Kreider RB. Ireland PJ, Hardy T, Burt AD, Donnelly MC. Information from this source is evidence-based and objective, and without commercial influence. IV. Many patients do not consider herbal products to be medications. Answered by Dr. Brian Staiger, PharmD Herb-drug interactions: a literature review. If you have blood sugar problems, keep hard candies, glucose tablets, liquid glucose, or juice on hand for low blood sugar. Some medications, called sedatives, can also cause sleepiness and slowed breathing. 1998;20(1):191-198. 8600 Rockville Pike Taking ashwagandha along with these medications might decrease the effects of these medications. Green tea is a popular drink that originated in China and has been promoted for stomach disorders, to lower cholesterol, as an antioxidant, as a stimulant, and to lessen belly fat, among other uses. Ashwagandha has active ingredients of ashwagandha. View abstract. PLoS One 2009;4:e6628. Kava, native to the South Pacific, is a member of the pepper family. Available for Android and iOS devices. 2002 Sep 2;164(36):4161-5. Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. Drug interactions with herbs can be especially risky, too. Use with goldenseal is not recommended, as antipsychotic blood levels may rise leading to an irregular heart rhythm. Ashwagandha may have additive effects to certain drugs that are used for diabetes, high blood pressure, and low thyroid hormone, to name a few. 2 Pharmacokinetic interactions involve the processes by which warfarin is absorbed, distributed, metabolized, and excreted. You can look up your blood thinner at https://www.drugbank.ca/drugs/DB06228 (that's the page for Rivaroxaban / Xarelto but you can search for your blood thinner at the top right). Apricot Kernel - Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate, Phenethylamine (pea) - Magnesium Hydroxide (otc Drug), Bitter Orange - Potassium Chloride (prescription Drug). Liver Int. Enter other medications to view a detailed report. Lexapro's interactions with ashwagandha. 2020;34(5):1041-1059. OTHER NAME(S): Ajagandha, Amangura, Amukkirag, Asan, Asana, Asgan, Ashwagandha has most often been used by adults in doses up to 1000 mg daily, for up to 12 weeks. January 03, 2023 Be sure to check with your pharmacist or doctor if you use ginseng as an herbal supplement. Association of l-DOPA with recovery following Ayurveda medication in Parkinson's Disease. More are needed for more definitive results. Bjrnsson HK, Bjrnsson ES, Avula B, et al. View abstract. View abstract. ashwagandha and coumadin interactionmobile homes for rent in patterson, la. Chengappa KN, Bowie CR, Schlicht PJ, Fleet D, Brar JS, Jindal R. Randomized placebo-controlled adjunctive study of an extract of withania somnifera for cognitive dysfunction in bipolar disorder. Cureus. On xarelto, I've used plenty of herbs, including ashwagandha with no problems. Learn about supplement interactions with clopidogrel (Plavix). Becoming a Vegetarian: Foods to Choose From. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Some people should not take Ashwagandha, like those with thyroid issues or who are taking certain medications. View abstract. Cheah KL, Norhayati MN, Husniati Yaacob L, Abdul Rahman R. Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis. Review each herbal or prescription drug monograph and check for all possible drug interactions with your healthcare provider. Check other possible ginger-drug interactions here. What are the Side Effects of Ashwagandha? View abstract. Ginseng has been used in Asian countries for its therapeutic effects for centuries. Sleep Med. Check the CoQ10 - warfarin interaction here. Long term effect of herbal drug Withania somnifera on adjuvant induced arthritis in rats. Interactions of clinical relevance associated with concurrent administration of prescription drug and food or medicinal plants: a systematic review protocol. Can you take ashwagandha and Orilissa together? Naturopathic care for anxiety: a randomized controlled trial ISRC TN78958974. Praveenkumar, V., Kuttan, R., and Kuttan, G. Chemoprotective action of Rasayanas against cyclosphamide toxicity. Dasgupta A, Tso G, Wells A. Patients must speak with a health care provider for complete information about their health, medical questions, and treatment options, including any risks or benefits regarding use of medications. Ugeskr Laeger. Vaishnavi, K., Saxena, N., Shah, N., Singh, R., Manjunath, K., Uthayakumar, M., Kanaujia, S. P., Kaul, S. C., Sekar, K., and Wadhwa, R. Differential activities of the two closely related withanolides, Withaferin A and Withanone: bioinformatics and experimental evidences. Immunopharmacol.Immunotoxicol. J Obstet Gynaecol Res 2021. These are drugs like diazepam, lorazepam, phenobarbital, or zolpidem. Stood up and gave a speech in front of 75 people without a single jitter for the first time in my life. In our latest question and answer, the pharmacist discusses whether or not ashwagandha supplements interact with prescription drugs. 2023 ConsumerLab.com, LLC. eCollection 2022. Khattak, S., Saeed, Ur Rehman, Shah, H. U., Khan, T., and Ahmad, M. In vitro enzyme inhibition activities of crude ethanolic extracts derived from medicinal plants of Pakistan. Ashwagandha side effects are rare and almost always mild. All rights reserved. 1998;60(2):173-178. You may need to have your International Normalized Ratio (INR) or other blood clotting lab test checked more frequently, or have your warfarin dose changed. These are somewhat complicated interactions that can lead to side effects or reduced effectiveness of your medicine, so always check with your pharmacist for drug interactions with herbal supplements. Evid Based Complement Alternat Med. WebMD does not provide medical advice, diagnosis or treatment. Lopresti AL, Smith SJ, Malvi H, Kodgule R. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study. View valerian drug interactions here. www.consumerlab.com/answers/which-supplements-should-be-avoided-when-taking-anticoagulants/warfarin-interactions/. Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study. Does Remeron interact with my other drugs? Menopause Symptoms & Stages: What Woman Need to Know. We comply with the HONcode standard for trustworthy health information. 2009;15(4):423-430. glipizide, glyburide, glimepride), SGLT2 Inhibitors (e.g. View abstract. It's not clear which of the ingredients had the benefit since ashwaganda is traditionally used in combination with other herbs. This site is intended for informational purposes only and not to provide medical advice. To prevent unnecessary adverse drug interactions, health care professionals need to be proactive in caring for their patients. Before Ashwagandha is an evergreen shrub that grows in Asia and Africa. Lets dive in: Looking for a tasty product that takes advantage ofmedicinal mushroom and nootropic ingredientslikethis? UpToDate, Inc. and its affiliates disclaim any warranty or liability relating to this information or the use thereof. Investigation of CYP2B6, 3A4 and -esterase interactions of Withania somnifera (L.) dunal in human liver microsomes and HepG2 cells. However, the practical benefits and risks for people. Nat.Prod.Res 2005;19(6):567-571. J Ethnopharmacol 1999;67:233-39. drugs for diabetes and blood pressure). Personalize this study to your gender and age, Pramipexole Dihydrochloride and Abnormal Behavior, Rapamune and Left Ventricular Hypertrophy, Lantus Solostar and Vitamin E drug interaction, Gastroenteritis Pseudomonas and drugs of ingredients of prednisone. Indian J Exp Biol 1997;35:236-9. A systematic review and meta-analysis of randomized controlled trials. View abstract. Chandrasekhar K, Kapoor J, Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Pharmacol. In some parts of the world, people eat ashwagandha shoots, seeds, and fruit. Seek immediate medical attention if you experience any signs and symptoms of bleeding such as: Learn More: Melatonin: Worth Losing Sleep Over? View abstract. CYP3A4 inhibitors, such as grapefruit, can interact with certain medications by inhibiting the liver enzyme that metabolizes many drugs. Nutrients. MAOIs can also have interactions with certain foods such as aged cheeses and cured meats. I felt almost godlike with how comfortable I was at the podium. [Herbal medicines--evidence and drug interactions in clinical practice]. Fertil Steril 2010;94:989-96. Be sure to tell your doctor that you take this product if you are scheduled for surgery or tests. Lu, L., Liu, Y., Zhu, W., Shi, J., Liu, Y., Ling, W., and Kosten, T. R. Traditional medicine in the treatment of drug addiction. Information on laxative interactions with other medications and supplements such as Maalox, antibiotics, and statins and diabetes medications. The https:// ensures that you are connecting to the The drug interaction may be insignificant and no change may be needed; on the other hand, the interaction could be of concern and the herbal supplement may need to be discontinued, a drug dose changed, or a new medicine selected. The phase IV clinical study analyzes what interactions people who take Warfarin sodium and Maca maca have. Taking it with drugs that increase levels of thyroid hormone (e.g. Again, be sure to talk to your doctor about adding ashwagandha to immunosuppressant drugs. Does letrozole interact with my other drugs? p.46-62. View abstract. Here, well cover all of the potential Ashwagandha side effects and what to do when they arise. Currently on week 5 20mg Prozac and 600mg ksm-66 ashwagandha daily. Am J Drug Alcohol Abuse 2009;35(1):1-11. J Neurol Sci 2000;176:124-7. Effect of Withania somnifera (Ashwagandha) on the development of chemotherapy-induced fatigue and quality of life in breast cancer patients. selective serotonin reuptake inhibitors (SSRIs), slow down the absorption of iron from your body, Top 9 Ways to Prevent a Deadly Drug Interaction. There are over 20 listed interactions with saw palmetto, but most of these are minor interactions. The bark of yohimbe contains a chemical called yohimbine. View abstract. Otherwise, side effects are both rare and mild and can usually be remediated by adjusting your dosing routine. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. Warfarinherbal interactions can be classified based on pharmacokinetics and pharmacodynamics.2 Pharmacokinetic interactions involve the processes by which warfarin is absorbed, distributed, metabolized, and excreted.2 Warfarin is metabolized by cytochrome P450 isoenzymes (CYPs), with CYP2C9 being responsible for the majority of the metabolism of the S-enantiomer of warfarin, which is more potent than the R-enantiomer.2 Herbal supplements that have an effect on CYP3A4 or CYP2C19 are also expected to affect the plasma concentration of warfarin.2 These supplements alter warfarin plasma concentration through the inhibition or induction of warfarin protein binding. Andallu B, Radhika B. Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) root. Large doses can lead to an upset stomach, diarrhea, vomiting, and, in rare cases, liver problems. Xarelto has multiple elimination pathways. Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. We recommend checking outLucid Super Coffee. 1965;9(3):127-136. View abstract. Richards JS. OTC Medication Use In Pregnancy: Wise or Worrisome? It may be used by some people to help with rheumatoid arthritis and nerve pain in diabetes, also called diabetic neuropathy.. Evening primrose oil provides fatty acids used by the body for growth. 2021 Feb 11;6(1):20. doi: 10.3390/jfmk6010020. Don't forget to spice it up with your favorite aromatics! Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. While avoidance of medications in pregnancy is the best course of action, this is not Society tends to treat menopause as a disease; something to be avoided at all costs. Please do not submit any type of HTML markup or scripting as it will not be accepted, nor will posts that exceed 2,500 characters. Phytother Res 1991;5:111-14. Hu Z, Yang X, Ho PC, Chan SY, Heng PW, Chan E, Duan W, Koh HL, Zhou S. Drugs. The interactions between warfarin and medicinal herbs described in the literature have been summarized in this paper relying on Medline database (via PubMed) using the key words: warfarin, herbal supplements and interactions. Ask your doctor for advice about forms of ashwagandha and doses. As always, be sure to talk to your doctor about combining any over-the-counter dietary supplement with your prescribed drugs as they have your complete medical profile. Kulkarni S. Progress in Neuro-Psychopharmacology and Biological Psychiatry, July 2008; vol 32: pp 1093-1105. You may need to have your blood clotting tests checked more frequently and may need a change in your anticoagulant dose. Side effects of Ashwagandha are often related to poor product quality, so choosing a high-quality manufacturer is of utmost importance. J R Coll Physicians Edinb. Learn more about vitamin K, including info on interactions with blood thinners such as Coumadin and Jantoven, its effects on bones & impact on clotting. Answer (1 of 8): 12 Proven Health Benefits of Ashwagandha and Ashwagandha: It's Powerful Health and Beauty Benefits You Didn't Know About and Ashwagandha: Health benefits and side effects Ashwagandha itself works as a antidepressant. Some lab tests of cancer cells have found that ashwagandha might slow down their growth. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Prez-Gmez J, Villafaina S, Adsuar JC, Merellano-Navarro E, Collado-Mateo D. Effects of ashwagandha (Withania somnifera) on VO2max: A systematic review and meta-analysis. Effect of Asian ginseng, Siberian ginseng, and Indian ayurvedic medicine Ashwagandha on serum digoxin measurement by Digoxin III, a new digoxin immunoassay. Even though herbal supplements may be from plant or herb sources, the active ingredients can still be potent chemicals. In most cases, Ashwagandha has shown to have little to no risk of adverse effects. Change in balance, feeling shaky, or unsteady, Not able to think clearly or change in thinking, US Department of Defense Dietary Supplement Resource, https://www.opss.org/article/ashwagandha-dietary-supplement-products, This generalized information is a limited summary of diagnosis, treatment, and/or medication information. Potential herb-drug interactions are of a major safety concern, especially for drugs with narrow therapeutic indices like warfarin, which can lead to severe adverse reactions that are sometimes life-threatening. All rights reserved. Information about MenaQ7, a MK-7 form of vitamin K2, including test results for a supplement containing MenaQ7. November 30, 2021November 30, 2021. camara conservation area Mechanism of CoumadinHerbal Interactions. Ginkgo has been promoted to be used for treating anxiety, dementia, circulation problems in the legs, premenstrual sydrome, certain vision problems, dizziness, or some movement disorders. Consult your health care provider before taking if you are pregnant or nursing, or have any other medical conditions. This holds true for ashwagandha. National Institute of Health (NIH). No. Akhgarjand C, Asoudeh F, Bagheri A, et al. Check with your doctor or pharmacist for a drug interaction review with St. John's Wort if you take prescription, OTC, vitamin or other herbal or dietary medications.
In general, Ashwagandha is thought to be safe when used in moderate amounts. Hsu SM, Lin HJ, Kao YW, Li TM, Shia BC, Huang ST. PLoS One. Although ashwagandha is one of the more well-studied herbals on the market, there have not been extensive drug-interaction studies with it. Office of Dietary Supplements. Some mixtures of medications can lead to serious and even fatal consequences. Pharmacol Biochem.Behav 2003;75(3):547-555. Anbalagan, K. and Sadique, J. J Ethnopharmacol 1999;64:91-3. Is Zoloft Safe To Take With Boswellia And Turmeric? Call your doctor immediately if you have fever, joint pain, bleeding, skin rash or itch, appetite loss, fatigue, nausea/vomiting, stomach pain, dark colored urine, light colored stools, and/or yellowing of the skin/eyes; these may be signs of liver toxicity. Symptoms of an allergic reaction to Ashwagandha may include: In some cases, herbal remedies can interact with certain medications, including other supplements and OTC and prescription drugs. Medically reviewed by Drugs.com. Learn more about the possible counteractive effects of CoQ10 and blood thinners, including safety. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. So truly speaking there may not any need of taking both ashw. Effect of standardized root extract of ashwagandha (Withania somnifera) on well-being and sexual performance in adult males: a randomized controlled trial. Women who are breastfeeding should also not use the herb.. Elite Continuing Education CE. J Med Food 2022. Go to the ER right away. Mushroom tea is super simple. Studies are inconclusive, but ashwagandha may have immune-stimulating properties. 2016 Oct;83:14-21. doi: 10.1016/j.biopha.2016.06.012. Caffeine capsules are easy to come by, and it's trivially easy to buy or package up ashwagandha powder in capsule form. ConsumerLab.com's answer explains. However, the practical benefits and risks for people aren't clear yet. The references on the analyzed literature have been investigated in order to collect the existing data. View abstract. View abstract. 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Ashwagandha, also known as 'Indian Ginseng' is an evergreen shrub indigenous to India, the Middle East, and some parts of Africa. Ashwagandha Root (Withania somnifera): Analytical, quality control, and therapuetic monograph. Clot survivors is a support group for people who have survived blood clots. Its effects on arterial blood pressure in anaesthetized dogs. 2019;11(12):e6466. Ashwagandha can increase the activity of the immune system. official website and that any information you provide is encrypted Miller LG. all maps fatal bullet; who is running for senate in maryland 2022 Durg S, Bavage S, Shivaram SB. If on warfarin.don't take anything without Dr supervision. Can You Take Ashwagandha And Orilissa Together? Phytother Res 2022. eHealthMe is studying from 131,496 Coumadin users for its effectiveness, alternative drugs and more. View abstract. View abstract. The administration of these herbs and iron-containing supplements should be separated by several hours. Supplements that may interact with this medication include cannabidiol (CBD), grapefruit, St. John's wort, ginkgo and others. flowage lake west branch, mi ashwagandha and coumadin interaction. View abstract. Available for Android and iOS devices. It is thought to help reduce stress which may help aid in weight loss efforts. Of the total drug interactions, 133 are major, 491 are moderate, and 2 are minor. This information does not endorse any treatments or medications as safe, effective, or approved for treating a specific patient. There are 326 drugs known to interact with dextromethorphan, along with 1 alcohol/food interaction. ashwagandha and coumadin interaction. I noticed that KSM66 was better for anxiety in my case. One study, published in Phytotherapy Research, reported that ashwagandha supplementation reduced blood sugar and A1c levels, although this was a relatively small study. 2004;42(12):2015-2020. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Antiplatelet drugs such as clopidogrel; NSAIDs such as ibuprofen; Blood thinners such as warfarin St. Johns Wort is a popular herbal supplement widely used to help with symptoms of depression. Our phase IV clinical studies alone cannot establish cause-effect relationship. J Res Ayur Sid 1980;1:370-385. Kulkarni RR, Patki PS, Jog VP, et al. Drug interactions with ginger are not well documented; however, it is known to inhibit thromboxane synthetase, which can prolong bleeding time and may rarely cause interactions with anticoagulants like warfarin, aspirin, or other blood thinners. Next Steps to Take. Nevertheless there is a theoretical risk for potentiation, since the herb is thought to be a coumarin constituent. Health Sci Rep 2022;5(4):e741. Be sure to tell your doctor if you are breastfeeding. Gopal S, Ajgaonkar A, Kanchi P, et al. Ashwagandha contains several active constituents including: The mechanism of how ashwagandha works, for all of its purported benefits, is not well understood. The dietary supplement is most likely effective for coenzyme Q-10 deficiency, or reducing the symptoms of mitochondrial disorders, which are conditions that affect energy production in the cells. Yes, the effectiveness of warfarin (Coumadin), anisindione (Miradon) and other anticoagulant drugs prescribed to help prevent blood clots can be impacted by taking supplements. View abstract. 2019;98(37):e17186. View abstract. Ashwagandha side effects While the side effects of ashwagandha are minimal, some people may experience: Gastrointestinal upset. In the U.S., it has gained recent popularity due to claims it can boost metabolism and aid in weight loss. Due to the seriousness of many drug interactions, you should consult with your health care provider before using St. John's Wort. Let's face it, drug interactions are complicated, so have all of your medications -- even herbals, vitamins and other OTCs -- screened by your pharmacist to review for black cohosh drug interactions. PLoS.One. Phytother Res. The FDA can and does seize and remove from the market tainted, contaminated, fraudulent or unsafe dietary supplements when they are aware of problems.