no immunophenotypic abnormalities detected

Immunophenotype is a key parameter that is very valuable in predicting response to treatment as well as survival rates. no immunophenotypic abnormalities detected FREE COVID TEST lansing school district spring break 2021 Book Appointment Now. Tietz Clinical Guide to Laboratory Tests, 4th Edition: Saunders Elsevier, St. Louis, MO. Flow cytometry immunophenotyping may also be used: There are some other uses of this testing that are less common, but they are not addressed in this article. Earlier studies demonstrated that flow cytometric abnormalities are detected in multiple lineages (3-6) and correlate with morphology and cytogenetics (4,6). Rahul E, Ningombam A, Acharya S, Tanwar P, Ranjan A, Chopra A. Specimen Stability Information: Ambient/Refrigerated < or =96 hours, Slides: If possible, include 5 to 10 unstained bone marrow aspirate smears labeled with two unique identifiers. Br J Haematol. Available online at https://www.lls.org/managing-your-cancer/lab-and-imaging-tests/blood-tests#Immunophenotyping. For spinal fluid specimens: spinal fluid cell and differential counts are required. Clinical significance of surface antigen expression in children with acute myeloid leukemia: results of study AML-BFM-87. Available online at https://www.clinchem.org/cgi/content/full/46/8/1221. Most doctors wouldn't even bother doing a colposcopy and biopsy on a patient with ASCUS. Web: mayocliniclabs.com: Email: mcl@mayo.edu: Telephone: 800-533-1710: International: +1 855-379-3115: Values are valid only on day of printing For the individual abnormalities detected for each of the 27 immunophenotypic variables analyzed, a score was defined. All rights reserved. 3. Am J Med. As the number of abnormal cells increase in a lymph node, the size of the lymph node increases. Available online at https://www.cancer.org/cancer/acute-lymphocytic-leukemia/detection-diagnosis-staging/how-diagnosed.html. No abnormalities were detected for the other phenotypic markers analyzed, including 7.1 ( Table 2 ). 1985 Aug 29;313(9):534-8 Hanson CA: Acute leukemias and myelodysplastic syndromes. Clinical review on features and cytogenetic patterns in adult acute myeloid leukemia with lymphoid markers. Atypical cells don't necessarily mean you have cancer. Available online at https://www.cancer.org/cancer/leukemia-in-children/detection-diagnosis-staging/how-diagnosed.html. American Cancer Society. SI Abnormal Reports. The prognostic value of immunophenotyping in AML is controversial [ 3]. Phenotypic analysis by flow cytometry of surface immunoglobulin light chains and B and T cell antigens in lymph nodes involved with non-Hodgkin's lymphoma. (Reviewed 2010 December). Flow lymphoma is used in the case of lymphoid neoplasms or when a lymphoid origin is suspected on the basis of cell morphology after staining. although diagnostic criteria are well established, a no immunophenotypic myeloid abnormalities were detected in the healthy donor bone marrow aspirates or in the 10 remission bone marrow aspirates from patients with a history of nonmyeloid neoplasia table 3, as mentioned, the immunophenotypic panels used evolved during the study, and not all The translocation t(9;22)(q34;q11.2) was detected by conventional chromosomal analysis in 59 patients (91%) the Ph-positive ALL cohort. If not ordering electronically, complete, print, and send 1 of the following forms with the specimen: -Hematopathology/Cytogenetics Test Request (T726). Immunophenotypic features of acute myeloid leukemia with inv(3)(q21q26.2)/t(3;3)(q21;q26.2). In the present study, we describe both quantitative and qualitative immunophenotypic abnormalities involving BM B-cells in MDS patients. It is not offered in every laboratory, but many larger hospitals and academic medical centers perform the testing or your sample may be sent to a reference laboratory. I just had a colposcopy done to follow up on an ASCUS pap with high risk HPV. BM: hematogones . The triage panel also includes antibodies to assess the number of CD3-positive T cells and CD16-positive/CD3-negative natural killer (NK) cells present. Available online at https://www.cancer.org/acs/groups/cid/documents/webcontent/003109-pdf.pdf. The results may also be used to predict how aggressive the cancer will be and/or whether it will respond to certain treatment. Cheriyedath, Susha. Immunophenotyping has become extremely important not only in diagnosis and subclassification of AML but also in the detection of the minimal residual disease. An official website of the United States government. MDS is distinguished from other disease processes by a pattern of multiple myeloid immunophenotypic abnormalities (3-6). (2019 January 3, Updated). This panel, together with the provided clinical history and morphologic review, is used to determine what, if any, additional testing is needed for disease diagnosis or classification. Conclusion: Only 5 similar cases have been described previously. As the number of abnormal cells increases in the bone marrow, they may crowd out and inhibit the production of normal white blood cells, red blood cells, and platelets, and eventually abnormal cells may also be released into the blood. News-Medical.Net provides this medical information service in accordance HHS Vulnerability Disclosure, Help Initial evaluation of . 1985 May;134(5):2995-3002 Among T-cell populations outside the thymus, phenotypes associated with malignancy included 1) loss of pan-T antigens (including loss of the beta chain of the T-cell antigen receptor), 2) coexpression or loss of T-subset antigens, 3) Leu-6+ T-lineage, and 4) MB-1+ T lineage. In this example, abnormal CD34-positive blasts show uniform expression of CD56 and partial expression of CD7. Cancers (Basel). [On-line information]. Study shows COVID-19 rates were likely forty-times higher than CDC estimates during BA.4/BA.5 dominant period in the U.S. Popular artificial sweetener associated with elevated risk of heart attack and stroke, study shows, Study supports the concept of atherosclerosis as a T-cell autoimmune disease targeting the arterial wall, New method can potentially catch COVID-19 infections quickly with near-perfect accuracy, Evidence that cross-reactive immunity from common human coronaviruses can influence response to SARS-CoV-2, The Effect of Intermittent Fasting on the Gut Microbiome, The Impact of Cyberbullying on Mental Health, Association between cardiovascular disease and transportation noise revealed in new research, Novel predictors of severe respiratory syncytial virus infections among infants below the age of one, Naked mRNA delivered using needle-free PYRO injection presents a safe and effective potential vaccination method, Innovative method to spot bacteria in blood, wastewater, and more, Associations between structural brain alterations and post-COVID fatigue, Reactive and neoplastic expansions of lymphocytes, Fluid suspensions (sample): flow cytometry (test method), Cells on slides (sample): immunocytochemistry (test method). More practically, and although the relationships demonstrated only represent a fraction of homogeneous immunophenotypic subgroups, identification of such immunophenotypic features should prompt careful karyotypic examination, eventually using molecular biology analysis on non-growing cells. sharing sensitive information, make sure youre on a federal These tests may suggest lymphoma or leukemia, but more information is generally needed to confirm a diagnosis and to identify a specific type of leukemia or lymphoma. Body fluid samples are obtained through collection of the fluid in a container or by inserting a needle into the body cavity and aspirating a portion of the fluid with a syringe. Acute Lymphoblastic Leukemia. We describe the clinicopathologic, cytogenetic, and molecular genetic characteristics of 14 cases of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) with t(14;19)(q32;q13). Cytometry B Clin Cytom. Although the World Health Organization classification of AML takes into account immunophenotypic features, the criteria for the same in monocytic AML is not clearly defined. In general, these criteria involved identification of abnormal expression or loss of antigens in B- and T-lineage populations. There is a dim Kappa expression and dim CD20 expression. -Bone Marrow Staging for Known or Suspected Malignant Lymphoma Algorithm, -Acute Myeloid Leukemia: Testing Algorithm, -Acute Myeloid Leukemia: Relapsed with Previous Remission Testing Algorithm, -Acute Promyelocytic Leukemia: Guideline to Diagnosis and Follow-up, -Mast Cell Disorder: Diagnostic Algorithm, Bone Marrow, -Acute Leukemias of Ambiguous Lineage Testing Algorithm, Acute Leukemia -- Immunophenotyping, Flow Cytometry, Chronic Lymphocytic Leukemia, Immunophenotyping, Flow Cytometry, Flow Cytometry, Leukemia Immunophenotyping, Flow Cytometry, Lymphoma Immunophenotyping, Lymphoma Immunophenotyping by Flow Cytometry, GLL Panel - Leukemia Immunophenotyping (ALWAYS order LCMS), Granular Lymphocytic Leukemia (ALWAYS order LCMS), KIR Panel - Leukemia Immunophenotyping (ALWAYS order LCMS), LGL Panel - Leukemia Immunophenotyping (ALWAYS order LCMS), NK Panel - Leukemia Immunophenotyping (ALWAYS order LCMS), B-cell ALL minimal residual disease (MRD) detection. 2010 Sep;34(9):1235-1238. doi: 10.1016/j.leukres.2010.03.020, Immunophenotypic features by multiparameter, Shi M, Ternus JA, Ketterling RP, et al: Immunophenotypic and laboratory features of t(11;14)(q13;q32)-positive plasma cell neoplasms. CSF cytology was negative for malignant cells. MeSH Rosado FG, Morice WG, He R, Howard MT, Timm M, McPhail ED: Immunophenotypic features by multiparameter flow cytometry can help distinguish low grade B-cell lymphomas with plasmacytic differentiation from plasma cell proliferative disorders with an unrelated clonal B-cell process. This site needs JavaScript to work properly. Rarely, no overt immunophenotypic abnormality will be present at diagnosis, and in these cases, the sensitivity of flow cytometric evaluation for minimal residual disease may be greatly reduced. Mature B cells are normally positive for CD20 but not CD34. Aggressive natural killer (NK) cell leukemia (ANKL) is a systemic neoplastic proliferation of NK cells with an aggressive clinical course. Frequent CD7 antigen loss in aggressive natural killer-cell leukemia: a useful diagnostic marker. while also discussing the various products Sartorius produces in order to aid in this. Leuk Lymphoma. JAMA Patient Page V301 (4) [On-line information]. Immunophenotypic characterization of the leukemic cells has been widely used as a tool for diagnosis, classification and prognosis of leukaemia. TdT and PAX5 were performed in five of the seven patients with ABLB detected by FC. al. 2022 Apr;71(4):919-932. doi: 10.1007/s00262-021-03051-x. This technique helps identify the lineage of cells using antibodies that detect markers or antigens on the cells, hence the immuno- prefix. In the present study, we describe both quantitative and qualitative immunophenotypic abnormalities involving BM B-cells in MDS patients. Flow cytometry immunophenotyping may be performed on blood, bone marrow, or other samples to provide this additional information. Please enable it to take advantage of the complete set of features! Leuk Lymphoma. A bone marrow sample may be collected from the hip bone by a trained health care practitioner (Bone Marrow Aspiration and Biopsy). Cuneo A, Ferrant A, Michaux JL, Boogaerts M, Demuynck H, Bosly A, Doyen C, Carli MG, Piva N, Castoldi G, et al. and transmitted securely. Chen, Y. If the CT scan said that there are no significant abnormalities it means that nothing out of the ordinary was noted. The interpretation will be based on markers tested in increments of 2 to 8, 9 to 15, or 16 and greater. Additional FISH or molecular testing may be recommended by the Mayo pathologist to facilitate diagnosis. Several studies have identified a relationship between AML prognosis and antigens such as CD7, CD9, CD11b, CD13, CD14, CD15, CD33, CD34, and CD56, though some other studies report conflicting results. Quest Diagnostics [On-line information]. Unable to load your collection due to an error, Unable to load your delegates due to an error. -TCL-1 break-apart at 14q32, to exclude T-cell prolymphocytic leukemia in cases with CD4-positive T-cell lymphoproliferative disorder (phenotypic aberrancy or very tight CD4+ population with high CD4:CD8 ratio). Jevremovic D, Dronca RS, Morice WG, et al: CD5+ B-cell lymphoproliferative disorders: Beyond chronic lymphocytic leukemia and mantle cell lymphoma. Human herpesvirus-encoded kinase induces B cell lymphomas in vivo. In this article, News-Medical talks to Sartorius about biosensing and bioprocessing in gene therapy, Bethesda, MD 20894, Web Policies 2018 Aug;59(8):1913-1919. doi: 10.1080/10428194.2017.1410885, Flow Cytometry Interpretation, 2 to 8 Markers (if appropriate), Flow Cytometry Interpretation, 16 or More Markers (if appropriate), Bone Marrow Staging for Known or Suspected Malignant Lymphoma Algorithm, Acute Myeloid Leukemia: Testing Algorithm, Acute Myeloid Leukemia: Relapsed with Previous Remission Testing Algorithm, Acute Promyelocytic Leukemia: Guideline to Diagnosis and Follow-up, Mast Cell Disorder: Diagnostic Algorithm, Bone Marrow, Acute Leukemias of Ambiguous Lineage Testing Algorithm, Hematopathology/Cytogenetics Test Request, Clients without access to Test Prices can contact, Prospective clients should contact their account representative. Immunocytochemistry is, however, limited by the quality and number of smears as one antibody is applied to one smear. Szary syndrome with multiple immunophenotypic aberrancies in tumor cells. (Updated 2011 March 13). According to the immunophenotype, MBL is labeled as chronic lymphocytic leukemia (CLL)-like (75% of cases), atypical CLL, and CD5-negative. Would you like email updates of new search results? Copyright 2013 Integrity Aesthetic & Wellness Center. 2019 Mar;96(2):99-115. doi: 10.1002/cyto.b.21768, 4. Additional FISH or molecular testing may be recommended by the Mayo pathologist to facilitate diagnosis. The type of sample to be tested is up to your healthcare practitioner and must be representative of your cancer. official website and that any information you provide is encrypted Upper endoscopy revealed a neoplastic growth at . If you have a leukemia or lymphoma, routine tests such as a complete blood count (CBC) and a WBC differentialmay show an increased number of white blood cells with a predominance of one type. Please enable it to take advantage of the complete set of features! Percentage of abnormal cells :91% B-cells, small size cells. Wittwera, C. and Brown, M. (2000). Federal government websites often end in .gov or .mil. Acute Lymphoblastic Leukemia (ALL). Miao Y, Zhang J, Chen Q, Xing L, Qiu T, Zhu H, Wang L, Fan L, Xu W, Li J. Bethesda, MD 20894, Web Policies 2. 2015 Sep-Oct;6[5]:435-440. doi: 10.6004/jadpro.2015.6.5.4). (Keren D, McCoy JP, Carey J: Flow Cytometry in Clinical Diagnosis. 1985 Oct;79(4):445-54. doi: 10.1016/0002-9343(85)90031-2. Furthermore, these findings can also be seen I got thre results today, which were "no significant abnormalities". In fact, these two markers are not normally expressed together. Khalidi HS, Medeiros LJ, Chang KL, Brynes RK, Slovak ML, Arber DA. PDF available for download at https://jama.ama-assn.org/content/301/4/452.full.pdf. Positive Ph status was the sole abnormality in 19 patients (32%) and was associated with other abnormalities in 43 patients (73%). Flow cytometric immunophenotyping evaluates individual cells in suspension for the presence and absence of specific antigens (phenotype). Korean J Lab Med. 2010 Sep;34(9):1235-1238. doi: 10.1016/j.leukres.2010.03.020, 2. However, lymphoma cells may or may not find their way to the bloodstream and might require other collection techniques. Careers. eCollection 2022. While some antigens are found only on one type of cell, others are found on different types. Lymphocyte counts do not usually correlate to changes in immune function or host resistance unless marked changes occur. It has become a common technique for the identification and classification of acute leukemias, particularly acute myeloid leukemia (AML). 1. Immunophenotyping detects the presence or absence of antigens found on the surface or interior of blood cells. These plasma cells are negative for CD19. 2008 December 1; 112(12): 43844399. 2022. FOIA Available online at https://emedicine.medscape.com/article/990113-overview. It can detect normal cells as well as abnormal cells whose pattern of markers are typically seen with specific types of leukemia and lymphoma. eCollection 2019. 1. ALL RIGHTS RESERVED. This site needs JavaScript to work properly. 8600 Rockville Pike (FNA09-1171; 9/30/09): No monotypic B cell population, phenotypically abnormal T cell population, or blast cell population detected. Leuk Res. Leuk Lymphoma. For bone marrow testing, if cytogenetic tests are desired along with this test request, an additional specimen should be submitted. This technique helps in prognostication and is also used to differentiate between neoplastic and reactive expansions of lymphocytes. The immunophenotype of adult acute myeloid leukemia: high frequency of lymphoid antigen expression and comparison of immunophenotype, French-American-British classification, and karyotypic abnormalities. Accessed December 2014. ( 2011). 88184-Flow cytometry; first cell surface, cytoplasmic or nuclear marker x 1, 88185-Flow cytometry; additional cell surface, cytoplasmic or nuclear marker (each), 88187-Flow Cytometry Interpretation, 2 to 8 Markers (if appropriate), 88188-Flow Cytometry Interpretation, 9 to 15 Markers (if appropriate), 88189-Flow Cytometry Interpretation, 16 or More Markers (if appropriate), Normal Reports | (33%) and in 15 of 17 (v)SAA patients (88%). (2016 February 3, Revised). Monoclonal B-cell lymphocytosis (MBL) is defined as a laboratory abnormality where small (<5 x 10(9)/L) clonal B-cell populations are detected in the peripheral blood of otherwise healthy subjects. Flow cytometry is generally used to determine cell lineage in leukemia and lymphoma. Please note that medical information found Mayo Clinic, Mayo Medical Laboratory [On-line information]. Application of immunophenotypic analysis in distinguishing chronic myelomonocytic leukemia from reactive monocytosis. Atypical or abnormal cells can demonstrate . NCI CPTC Antibody Characterization Program. Significant associations between immunophenotypic and karyotypic features were observed both within individual FAB subgroups and independently from morphological criteria. A positive correlation was found between CD34+ and CD34 B-cell precursors (r . A cell count should be determined and submitted with the specimen. It is concluded that immunophenotypic analysis of lymphoproliferative lesions is sufficiently sensitive and specific to confirm the histologic diagnosis of lymphoma in the vast majority of cases seen in clinical practice. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Clinical Laboratory Medicine. Accessed January 2020. ( 19952011). Accessed April 2011. 1. This is the most common type of abnormal Pap smear. In: McClatchey KD, ed. 2020 Oct 9;12(10):2900. doi: 10.3390/cancers12102900. no immunophenotypic abnormalities detected, failed to save changes to sbc squad companion app. Morice WG, Kimlinger T, Katzmann JA, et al: Flow cytometric assessment of TCR-Vbeta expression in the evaluation of peripheral blood involvement by T-cell lymphoproliferative disorders: a comparison with conventional T-cell immunophenotyping and molecular genetic techniques. -, N Engl J Med. Nat Rev Immunol v12 (3): 191200. The site is secure. No immunophenotypic myeloid abnormalities were detected in the healthy donor bone marrow aspirates or in the 10 remission bone marrow aspirates from patients with a history of nonmyeloid neoplasia (Table 3). Flow cytometry may be used to characterize and count types of white blood cells in the evaluation of infectious diseases, autoimmune disorders or immunodeficiencies. 1989 Dec;30(12):2134-40. 2020 May-Aug;24(2):195-199. doi: 10.4103/0973-029X.294653. It may be used in follow up to a complete blood count (CBC) and WBC differential that show an increased number of lymphocytes or the presence of immature blood cells or other abnormal cell counts. An abnormal karyotype was detected in 232 cases (54%). Accessed December 2014. Leukemia & Lymphoma Society [On-line information]. Trisomy 12 is the second most frequent aberration detected by fluorescence in situ hybridization at the time of diagnosis (10-25%), and it confers an intermediate prognostic risk, with a median time to . National Library of Medicine The https:// ensures that you are connecting to the Available online at https://arupconsult.com/content/acute-lymphoblastic-leukemia. Epub 2018 Aug 6. PMC No flow cytometric abnormalities were detected in CD4-positive T-cells from 10 control patients without lymphoproliferative disorders. They do not die at a normal rate, so they accumulate in the bone marrow, lymph nodes, or other tissues. The https:// ensures that you are connecting to the Immunophenotyping, a common application in flow cytometry, allows multiple cell surface markers to be simultaneously characterized on a per-cell basis.Immunophenotyping can be difficult by flow cytometry, however, when only a small number of cells are available. Flow cytometry immunophenotyping may be ordered when you have an increased number of lymphocytes (or sometimes an increase in another type of white blood cell, WBC), anemia, a decreased platelet count, or immature WBCs that are not normally seen in the blood. Anaplastic lymphoma kinase protein was detected in about 33% (3/9) of ALCLs examined by flow cytometric immunophenotyping (FCI); expression was validated by immunohistochemical analysis. News-Medical. 2004 Mar;121(3):373-383. doi: 10.1309/3A32-DTVM-H640-M2QA, 7. Flow cytometric immunophenotyping is of great value to diagnosis of natural killer cell neoplasms involving bone marrow and peripheral blood. Large granular lymphocytic leukemia: a brief review. The most common patterns of post-relapse FISH dissimilarity were loss of previously detected hyperdiploidy, seen in three (33.3%) cases, and gain of 1q21 in three (33.3%) cases. Trisomy 12 is the second most frequent aberration detected by fluorescence in situ hybridization at the time of diagnosis (10-25%), and it confers an . Sometimes, however, the cancer cells adapt to evade the therapy by not expressing anymore an antigen that they expressed earlier, which might have been targeted by a monoclonal antibody or other therapy, like CAR T-cells. Accessed December 2014. and transmitted securely. Accessed April 2011. (2009 January 28). MeSH -MYC break-apart at 8q24, with or without IGH-BCL2 t(14;18) and BCL6 break-apart at 3q27, for suspected high grade B-cell lymphomas, based on morphologic assessment and immunophenotype (usually CD10-positive). Siba El Hussein, Keyur P. Patel, Hong Fang, Beenu Thakral, Sanam Loghavi, Rashmi Kanagal-Shamanna, Sergej Konoplev, Elias J. Jabbour, L. J. Jeffrey Medeiros, Joseph D. Khoury Furthermore, these findings can also be seen Incidence of peripheral lymphadenopathy, hepatic abnormalities, splenic abnormalities, and abdominal lymphadenopathy was not significantly different among immunophenotypic groups. government site. Flow cytometric immunophenotyping is a valuable addition to morphology in the diagnosis of MDS in adults.7 Abnormalities detected by flow cytometry in myelomonocytic, . Sometimes lymphomas also involve the blood and/or bone marrow. government site. Multivariate analysis identified CD34 and CD9 expression as independently predictive of the presence of at least one cytogenetic abnormality (P < 10(-4) and P < 0.03, respectively). Fonatsch C, Gudat H, Lengfelder E, Wandt H, Silling-Engelhardt G, Ludwig WD, Thiel E, Freund M, Bodenstein H, Schwieder G, et al. The third parameter for assessing dysplasia by flow cytometry is maturation pattern of granulocytes on CD13/CD16 plot. Abnormal Reports, SI Normal Reports | Blood Tests. Flow Cytometry: Principles and Clinical Applications in Hematology Clinical Chemistry 46:8(B) 12211229 [On-line information]. 2013 Jul;346(1):56-63. doi: 10.1097/MAJ.0b013e3182764b59. Chronic lymphocytic leukemia is an extremely heterogeneous disease and prognostic factors such as chromosomal abnormalities are important predictors of time to first treatment and survival. Would you like email updates of new search results? How To Create Google Form Link In Mobile, Seiter, K. (2018 July 17, Updated). Am J Clin Pathol. I got thre results today, which were "no significant abnormalities". We use cookies to enhance your experience. 7 In summary, blasts of AMoL can be. Hexosamine Biosynthetic Pathway Inhibition Leads to AML Cell Differentiation and Cell Death. The immunophenotype of ANKL cells may differ from reactive NK cells in 4 respects. ARUP Consult [On-line information]. low reading R03.1 . The .gov means its official. Hu X, Yang Y, Chen L, Wan Y, Sheng L, Bao Y, Zheng M. Am J Transl Res. Pp 1633-1711. Jevremovic D, Olteanu H: Flow cytometry applications in the diagnosis of T/NK-cell lymphoproliferative disorders. Because of this, immunophenotyping results will be different by reflecting the current population of WBCs that would be present in an individual in remission. Leukemia & Lymphoma Society [On-line information]. Blood Journal v111 (8) [On-line information]. Disclaimer. Bethesda, MD 20894, Web Policies -A monoclonal Kappa B-cell population co-expression CD5, CD11c and CD23 is present. An interpretation of the immunophenotypic findings and correlation with the morphologic features will be provided by a hematopathologist for every case. Genomic and immunophenotypic landscape of aggressive NK-cell leukemia. Case presentation We report the case of a 64-year-old woman with gastric primary myeloid sarcoma with monocytic differentiatio. You may have (or lack) certain antigens that are typically seen, yet you may still be diagnosed with a specific type of leukemia or lymphoma. The overall incidence of different immunophenotypic aberrancies among the 44 MF/SS patients is summarized in Table 1. . Rereview of PB smears from these patients, who had typical cutaneous findings of MF, did not identify definitive Sezary cells. Jiang NG, Jin YM, Niu Q, Zeng TT, Su J, Zhu HL. degree in Chemistry and Master of Science (M.Sc) degree in Biochemistry from the University of Calicut, India.